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WHAT WE DO?

Malaria represents one of the main Public Health problems with greater weight in morbidity and mortality, in the world and in Mozambique in particular. According to the WHO, it is estimated that in 2018 about 228 million cases of malaria and 405 thousand deaths were estimated globally; of these cases, 93% (213 million) occurred in sub-Saharan Africa. Mozambique is one of the ten countries with the highest weight of malaria in the world, with the disease being responsible for about 29% of all deaths (42% in children under 5 years old). Data from the survey of malaria indicators carried out in 2018, indicate that the prevalence of malaria in children under 5 years old was 39% in Mozambique, ranging from 1% in the City and Province of Maputo to 57% in the province of Cabo Delgado.

 

The investment in research for malaria has been increasing with the relaunch of the objective of eliminating malaria through the global technical strategy for malaria launched in 2015 by WHO; as well as the most recent initiative, also by WHO, called “High Burden High Impact” (HBHI) launched in Maputo in November 2018 which aims to accelerate malaria control measures in 10 African countries plus India. These countries, including Mozambique, contribute more than 70% of the global weight of malaria. Both strategies mentioned above have research as an essential pillar to guide the implementation of activities based on scientific evidence.

The history of CISM is associated with the RTS,S malaria vaccine development initiative, which contributed to the development of human and institutional capacity for research in this area.

The tools currently available are still insufficient to achieve effective malaria control. In addition to the question of the parasite's resistance to antimalarial medication and the vector to insecticides, these tools are not fully effective, and there is a need to continue working on the development of new control tools (prevention and treatment) and/or elimination of malaria.

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Main objectives

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  • Design and implement innovative strategies for the control and/or elimination of malaria at different levels of transmission in Mozambique

  • Understand the pathophysiological and immunological mechanisms of malaria, including the identification of critical pathogenic events in parasite sequestration and resistance to antimalarial medication

  • Participate in clinical trials of drugs and vaccines against malaria

  • Develop entomological intelligence and participate in the development of new tools for vector control

  • Develop implementation research, in accordance with the research agenda of the National Malaria Control Program (attached), which can contribute to guide the implementation of the program in the areas of communication for behavior change, vector control, prevention of malaria in pregnancy and case management.

o que fazemos
PI

TEAM

Pedro Aide.jpeg

Pedro Aide

Coordinator

  • LinkedIn - círculo cinza

His main area of research is malaria, one of the main health problems that mainly affects children and pregnant women, in Mozambique in particular. He has been involved in several malaria-related research projects as a co-principal investigator and investigator, among other studies on malaria prevention and control, including intermittent preventive treatment trials in infants (IPTi) and clinical evaluation of safety, efficacy and immunogenicity of the most advanced malaria vaccine candidate, RTS, S/AS0. He is currently one of the researchers in the PAMAFRICA project in Mozambique.

Download CV here

PROJECTS

Projctos

  • AGEAL. Age of Exposure and Immunity to Malaria

  • ASYMPTOM. Unraveling disease tolerance and host resistance in afebrile P. falciparum infections: a prospective study in Mozambican adults

  • BOVA/HUT2. Mosquito screening entry points into houses with novel long-lasting insecticidal netting to reduce indoor vector densities and mitigate pyrethroid-resistance

  • COST. Evaluation of the cost-effectiveness of 3rd generation indoor residual spraying as a malaria control strategy

  • CytoMal. Cellular biomarkers of exposure and immunity to malaria

  • GEPI. Genetic Epidemiology of Plasmodium falciparum in southern Mozambique

  • MAL067. Immunological study of the RTS,S malaria vaccine in the phase 3 trial

  • MANICA. Cross Border Malaria Transmission along the Zimbabwe-Mozambique Border

  • MEFI. Molecular markers of Plasmodium falciparum resistance to antimalarials in different regions of Mozambique

  • MIPMON. Pregnant women as sentinel group for malaria surveillance in an area of ​​changing malaria transmission

  • MOSASWA/VIMAG2. Improved Entomological Intelligence in southern Mozambique

  • SEVMAL2. Identification of strain-transcending anti-adhesion targets from virulent Plasmodium falciparum malaria parasites

  • SYSTEM Health Management Information System Baselin Assessment

  • REACT/MDA. Mass Drug Administration of Monthly DHA-PQP Accelerates Towards Malaria Elimination in Magude District, Southern Mozambique (MDA): Reactive Malaria Case Detection and Response to Towards Malaria Elimination in Southern Mozambique​

  • ROSI Rosiglitazone adjunctive therapy for severe malaria in children

  • TRANSECT/DAYTIME. Transect study in Mnahiça district to inform the extent of larval source management at finer scales + day time biting of malaria mosquitoes

  • VECE-IRS. Assessing the efficacy of vector control tools in killing malaria mosquitoes in Magude and Manhiça district

  • XMAG/XMAL. Transverse Malaria Prevalence Studies in Magude (XMAG) and Manhica (XMAL)

  • XMAL_19. Cross-sectional studies to monitor the burden of malaria and impact of different malaria control tools in Manhiça, Mozambique

Other ongoing projects

Publicações

​LATEST NEWS

PUBLICATIONS (2020)

Authors
Title
Journal
Oruko K, Maixenchs M, Phillips-Howard P, Ondire M, Akelo C, Sanz A, Ordi J, Menéndez C, Bassat Q, Odhiambo FO, Munguambe K.
Conceptual frameworks for understanding the acceptability and feasibility of the minimally invasive autopsy to determine cause of death: Findings from the CADMIA Study in western Kenya.
PLoS One. 2020 Dec 14;15(12):e0242574. doi: 10.1371/journal.pone.0242574. eCollection 2020.PMID: 33315918
Galatas B, Mayor A, Gupta H, Balanza N, Jang IK, Nhamussua L, Simone W, Cisteró P, Chidimatembue A, Munguambe H, Saúte F, Aide P, Bassat Q.
Field performance of ultrasensitive and conventional malaria rapid diagnostic tests in southern Mozambique.
Malar J. 2020 Dec 7;19(1):451. doi: 10.1186/s12936-020-03526-9.PMID: 33287822 
Pons-Duran C, Llach M, Sacoor C, Sanz S, Macete E, Arikpo I, Ramírez M, Meremikwu M, Mbombo Ndombe D, Méndez S, Manun'Ebo MF, Ramananjato R, Rabeza VR, Tholandi M, Roman E, Pagnoni F, González R, Menéndez C.
Coverage of intermittent preventive treatment of malaria in pregnancy in four sub-Saharan countries: findings from household surveys.
Int J Epidemiol. 2020 Dec 8:dyaa233. doi: 10.1093/ije/dyaa233. Online ahead of print.PMID: 33349871
Enguita-Fernàndez C, Alonso Y, Lusengi W, Mayembe A, Manun'Ebo MF, Ranaivontiavina S, Rasoamananjaranahary AM, Mucavele E, Macete E, Nwankwo O, Meremikwu M, Roman E, Pagnoni F, Menéndez C, Munguambe K.
Trust, community health workers and delivery of intermittent preventive treatment of malaria in pregnancy: a comparative qualitative analysis of four sub-Saharan countries.
Glob Public Health. 2020 Dec 8:1-15. doi: 10.1080/17441692.2020.1851742. Online ahead of print.PMID: 33290172
Suau R, Vidal M, Aguilar R, Ruiz-Olalla G, Vázquez-Santiago M, Jairoce C, Nhabomba AJ, Gyan B, Dosoo D, Asante KP, Owusu-Agyei S, Campo JJ, Izquierdo L, Cavanagh D, Coppel RL, Chauhan V, Angov E, Dutta S, Gaur D, Beeson JG, Moncunill G, Dobaño C.
RTS,S/AS01E malaria vaccine induces IgA responses against CSP and vaccine-unrelated antigens in African children in the phase 3 trial.
Vaccine. 2020 Dec 24:S0264-410X(20)31606-6. doi: 10.1016/j.vaccine.2020.12.038. Online ahead of print.PMID: 33358704
Bone JN, Pickerill K, Woo Kinshella ML, Vidler M, Craik R, Poston L, Stones W, Sevene E, Temmerman M, Koech Etyang A, Roca A, Russell D, Tribe RM, von Dadelszen P, Magee LA; PRECISE Network.
Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review.
BMJ Glob Health. 2020 Nov;5(11):e003716. doi: 10.1136/bmjgh-2020-003716.PMID: 33243854 
Ginsburg AS, Lenahan JL, Jehan F, Bila R, Lamorte A, Hwang J, Madrid L, Nisar MI, Vitorino P, Kanth N, Balcells R, Baloch B, May S, Valente M, Varo R, Nadeem N, Bassat Q, Volpicelli G.
Performance of lung ultrasound in the diagnosis of pediatric pneumonia in Mozambique and Pakistan.
Pediatr Pulmonol. 2020 Nov 18. doi: 10.1002/ppul.25176. Online ahead of print.PMID: 33205892
Colston JM, Faruque ASG, Hossain MJ, Saha D, Kanungo S, Mandomando I, Nisar MI, Zaidi AKM, Omore R, Breiman RF, Sow SO, Roose A, Levine MM, Kotloff KL, Ahmed T, Bessong P, Bhutta Z, Mduma E, Penatero Yori P, Sunder Shrestha P, Olortegui MP, Kang G, Lima AAM, Humphrey J, Prendergast A, Schiaffino F, Zaitchik BF, Kosek MN.
Associations between Household-Level Exposures and All-Cause Diarrhea and Pathogen-Specific Enteric Infections in Children Enrolled in Five Sentinel Surveillance Studies.
Int J Environ Res Public Health. 2020 Nov 2;17(21):8078. doi: 10.3390/ijerph17218078.PMID: 33147841
Valenciano SJ, Moiane B, Lessa FC, Chaúque A, Massora S, Pimenta FC, Mucavele H, Verani JR, da Gloria Carvalho M, Whitney CG, Tembe N, Sigaúque B.
Effect of 10-Valent Pneumococcal Conjugate Vaccine on Streptococcus pneumoniae Nasopharyngeal Carriage Among Children Less Than 5 Years Old: 3 Years Post-10-Valent Pneumococcal Conjugate Vaccine Introduction in Mozambique.
J Pediatric Infect Dis Soc. 2020 Nov 27:piaa132. doi: 10.1093/jpids/piaa132. Online ahead of print.PMID: 33245124
Chaguza C, Yang M, Cornick JE, du Plessis M, Gladstone RA, Kwambana-Adams BA, Lo SW, Ebruke C, Tonkin-Hill G, Peno C, Senghore M, Obaro SK, Ousmane S, Pluschke G, Collard JM, Sigaùque B, French N, Klugman KP, Heyderman RS, McGee L, Antonio M, Breiman RF, von Gottberg A, Everett DB, Kadioglu A, Bentley SD.
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.
Commun Biol. 2020 Oct 8;3(1):559. doi: 10.1038/s42003-020-01290-9.PMID: 33033372
Magaço A, Munguambe K, Nhacolo A, Ambrósio C, Nhacolo F, Cossa S, Macete E, Mandomando I.
Challenges and needs for social behavioural research and community engagement activities during the COVID-19 pandemic in rural Mozambique.
Glob Public Health. 2020 Oct 30:1-5. doi: 10.1080/17441692.2020.1839933. Online ahead of print.PMID: 33125306
Etti M, Sekikubo M, Nankabirwa V, Sommerfelt H, Freyne B, Kawaza K, Gadama G, Jambo K, Sevene E, Temmerman M, Magee LA, von Dadelszen P, Khalil A, Doare KL; WHO/HRP Alliance author group.
SARS-CoV-2 Infection in Pregnant Women and Their Newborns.
Ann Glob Health. 2020 Oct 8;86(1):132. doi: 10.5334/aogh.3072.PMID: 33102152
Pavlinac PB, Platts-Mills JA, Tickell KD, Liu J, Juma J, Kabir F, Nkeze J, Okoi C, Operario DJ, Uddin MJ, Ahmed S, Alonso PL, Antonio M, Becker SM, Breiman RF, Faruque ASG, Fields B, Gratz J, Haque R, Hossain A, Hossain MJ, Jarju S, Qamar F, Iqbal NT, Kwambana B, Mandomando I, McMurry TL, Ochieng C, Ochieng JB, Ochieng M, Onyango C, Panchalingam S, Kalam A, Aziz F, Qureshi S, Ramamurthy T, Roberts JH, Saha D, Sow SO, Stroup SE, Sur D, Tamboura B, Taniuchi M, Tennant SM, Roose A, Toema D, Wu Y, Zaidi A, Nataro JP, Levine MM, Houpt ER, Kotloff KL.
The clinical presentation of culture-positive and culture-negative, qPCR-attributable shigellosis in the Global Enteric Multicenter Study and derivation of a Shigella severity score: implications for pediatric Shigella vaccine trials.
Clin Infect Dis. 2020 Oct 12:ciaa1545. doi: 10.1093/cid/ciaa1545. Online ahead of print.PMID: 33044509
Gupta H, Galatas B, Chidimatembue A, Huijben S, Cisteró P, Matambisso G, Nhamussua L, Simone W, Bassat Q, Ménard D, Ringwald P, Rabinovich NR, Alonso PL, Saúte F, Aide P, Mayor A.
Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance.
PLoS One. 2020 Oct 19;15(10):e0240174. doi: 10.1371/journal.pone.0240174. eCollection 2020.PMID: 33075062
Mousa A, Al-Taiar A, Anstey NM, Badaut C, Barber BE, Bassat Q, Challenger JD, Cunnington AJ, Datta D, Drakeley C, Ghani AC, Gordeuk VR, Grigg MJ, Hugo P, John CC, Mayor A, Migot-Nabias F, Opoka RO, Pasvol G, Rees C, Reyburn H, Riley EM, Shah BN, Sitoe A, Sutherland CJ, Thuma PE, Unger SA, Viwami F, Walther M, Whitty CJM, William T, Okell LC.
The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis.
PLoS Med. 2020 Oct 19;17(10):e1003359. doi: 10.1371/journal.pmed.1003359. eCollection 2020 Oct.PMID: 33075101
Balanza N, Erice C, Ngai M, Varo R, Kain KC, Bassat Q.
Host-Based Prognostic Biomarkers to Improve Risk Stratification and Outcome of Febrile Children in Low- and Middle-Income Countries.
Front Pediatr. 2020 Sep 18;8:552083. doi: 10.3389/fped.2020.552083. eCollection 2020.PMID: 33072673 
Garrine M, Matambisso G, Nobela N, Vubil D, Massora S, Acácio S, Nhampossa T, Alonso P, Mandomando I.
Low frequency of enterohemorrhagic, enteroinvasive and diffusely adherent Escherichia coli in children under 5 years in rural Mozambique: a case-control study.
BMC Infect Dis. 2020 Sep 7;20(1):659. doi: 10.1186/s12879-020-05380-1.PMID: 32894092
Boisen N, Østerlund MT, Joensen KG, Santiago AE, Mandomando I, Cravioto A, Chattaway MA, Gonyar LA, Overballe-Petersen S, Stine OC, Rasko DA, Scheutz F, Nataro JP.
Redefining enteroaggregative Escherichia coli (EAEC): Genomic characterization of epidemiological EAEC strains.
PLoS Negl Trop Dis. 2020 Sep 8;14(9):e0008613. doi: 10.1371/journal.pntd.0008613. eCollection 2020 Sep.PMID: 32898134 
Singh H, Mian SY, Pandey AK, Krishna S, Anand G, Reddy KS, Chaturvedi N, Bahl V, Hans N, Shukla MM, Bassat Q, Mayor A, Miura K, Bharti PK, Long C, Singh N, Chauhan VS, Gaur D.
Antibody combinations targeting the essential antigens CyRPA, RH5 and MSP-119 potently neutralize Plasmodium falciparum clinical isolates from India and Africa.
J Infect Dis. 2020 Sep 29:jiaa608. doi: 10.1093/infdis/jiaa608.
García JI, Mambuque E, Nguenha D, Vilanculo F, Sacoor C, Sequera VG, Fernández-Quevedo M, Pierre ML, Chiconela H, Faife LA, Respeito D, Saavedra B, Nhampossa T, López-Varela E, Garcia-Basteiro AL.
Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out.
Sci Rep. 2020 Sep 22;10(1):15442. doi: 10.1038/s41598-020-71784-3.PMID: 32963296 
Magee LA, Sharma S, Sevene E, Qureshi RN, Mallapur A, Macuácua SE, Goudar S, Bellad MB, Adetoro OO, Payne BA, Sotunsa J, Valá A, Bone J, Shennan AH, Vidler M, Bhutta ZA, von Dadelszen P; & the Community-Level Interventions for Pre-eclampsia Study Group.
Population-level data on antenatal screening for proteinuria; India, Mozambique, Nigeria, Pakistan.
Bull World Health Organ. 2020 Oct 1;98(10):661-670. doi: 10.2471/BLT.19.248898. Epub 2020 Sep 9.PMID: 33177756 
Menendez YA, Cambaco O, Mindú C, Nhantumbo H, Uamusse T, Matsinhe G, Matsinhe B, Manjate RM, Bardají A, Menendez C, Sevene E, Munguambe K.
Lay knowledge of cervical cancer in Manhica district, Mozambique: a qualitative study.
Reprod Health. 2020 Aug 24;17(1):130. doi: 10.1186/s12978-020-00980-1.PMID: 32831101
von Dadelszen P, Bhutta ZA, Sharma S, Bone J, Singer J, Wong H, Bellad MB, Goudar SS, Lee T, Li J, Mallapur AA, Munguambe K, Payne BA, Qureshi RN, Sacoor C, Sevene E, Vidler M, Magee LA; CLIP Trials Working Group.
The Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials in Mozambique, Pakistan, and India: an individual participant-level meta-analysis.
Lancet. 2020 Aug 22;396(10250):553-563. doi: 10.1016/S0140-6736(20)31128-4.PMID: 32828187
Tessema SK, Hathaway NJ, Teyssier NB, Murphy M, Chen A, Aydemir O, Duarte EM, Simone W, Colborn J, Saute F, Crawford E, Aide P, Bailey JA, Greenhouse B.
Sensitive, highly multiplexed sequencing of microhaplotypes from the Plasmodium falciparum heterozygome.
J Infect Dis. 2020 Aug 25:jiaa527. doi: 10.1093/infdis/jiaa527. Online ahead of print.PMID: 32840625
Nhampossa T, Fernandez S, Augusto O, Fuente-Soro L, Maculuve SÓN, Bernardo E, Saura A, Casellas A, Gonzalez R, Ruperez M, Karajeans E, Vaz P, Menendez C, Buck WC, Naniche D, Lopez-Varela E.
Discordant retention of HIV-infected mothers and children: Evidence for a family-based approach from Southern Mozambique.
Medicine (Baltimore). 2020 Aug 7;99(32):e21410. doi: 10.1097/MD.0000000000021410.PMID: 32769871 
Galatas B, Saúte F, Martí-Soler H, Guinovart C, Nhamussua L, Simone W, Munguambe H, Hamido C, Montañà J, Muguande O, Maartens F, Luis F, Paaijmans K, Mayor A, Bassat Q, Menéndez C, Macete E, Rabinovich R, Alonso PL, Candrinho B, Aide P.
A multiphase program for malaria elimination in southern Mozambique (the Magude project): A before-after study.
PLoS Med. 2020 Aug 14;17(8):e1003227. doi: 10.1371/journal.pmed.1003227. eCollection 2020 Aug.PMID: 32797101
Nhama A, Varo R, Bassat Q.
Highlighting the burden of malarial infection and disease in the neonatal period: making sense of different concepts.
Malar J. 2020 Aug 28;19(1):311. doi: 10.1186/s12936-020-03394-3.PMID: 32859200
Taylor AW, Blau DM, Bassat Q, Onyango D, Kotloff KL, Arifeen SE, Mandomando I, Chawana R, Baillie VL, Akelo V, Tapia MD, Salzberg NT, Keita AM, Morris T, Nair S, Assefa N, Seale AC, Scott JAG, Kaiser R, Jambai A, Barr BAT, Gurley ES, Ordi J, Zaki SR, Sow
Initial findings from a novel population-based child mortality surveillance approach: a descriptive study.
Lancet Glob Health. 2020 Jul;8(7):e909-e919. doi: 10.1016/S2214-109X(20)30205-9.PMID: 32562647
Pimenta FC, Moiane B, Lessa FC, Venero AL, Moura I, Larson S, Massora S, Chaúque A, Tembe N, Mucavele H, Verani JR, Whitney CG, Sigaúque B, Carvalho MGS.
Dried blood spots for Streptococcus pneumoniae and Haemophilus influenzae detection and serotyping among children < 5 years old in rural Mozambique.
BMC Pediatr. 2020 Jul 2;20(1):326. doi: 10.1186/s12887-020-02209-3.PMID: 32615947
Cambaco O, Alonso Menendez Y, Kinsman J, Sigaúque B, Wertheim H, Do N, Gyapong M, John-Langba J, Sevene E, Munguambe K.
Community knowledge and practices regarding antibiotic use in rural Mozambique: where is the starting point for prevention of antibiotic resistance?
BMC Public Health. 2020 Jul 29;20(1):1183. doi: 10.1186/s12889-020-09243-x.PMID: 32727445 
Hopkins H, Bassat Q, Chandler CI, Crump JA, Feasey NA, Ferrand RA, Kranzer K, Lalloo DG, Mayxay M, Newton PN, Mabey D; FIEBRE Consortium.
Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE): protocol for a multisite prospective observational study of the causes of fever in Africa and Asia.
BMJ Open. 2020 Jul 21;10(7):e035632. doi: 10.1136/bmjopen-2019-035632.PMID: 32699131 
Moncunill G, Dobaño C, González R, Smolen KK, Manaca MN, Balcells R, Jairoce C, Cisteró P, Vala A,Sevene E, Rupérez M, Aponte JJ,Macete E, Menéndez C,Kollmann TR,Mayor A.
Association of Maternal Factors and HIV Infection With Innate Cytokine Responses of Delivering Mothers and Newborns in Mozambique.
Front Microbiol. 2020 Jul 14;11:1452. doi: 10.3389/fmicb.2020.01452. eCollection 2020.PMID: 32765436 
Menéndez C, Quintó L, Castillo P, Fernandes F, Carrilho C, Ismail MR, Lorenzoni C, Hurtado JC, Rakislova N, Munguambe K, Moraleda C, Maixenchs M, Macete E, Mandomando I, Martínez MJ, Alonso PL, Bassat Q, Ordi J.
Quality of care and maternal mortality in a tertiary-level hospital in Mozambique: a retrospective study of clinicopathological discrepancies.
Lancet Glob Health. 2020 Jul;8(7):e965-e972. doi: 10.1016/S2214-109X(20)30236-9.PMID: 32562652 
Cirera L, Galatas B, Alonso S, Paaijmans K, Mamuquele M, Martí-Soler H, Guinovart C, Munguambe H, Luis F, Nhantumbo H, Montañà J, Bassat Q, Candrinho B, Rabinovich R, Macete E, Aide P, Alonso P, Saúte F, Sicuri E.
Moving towards malaria elimination in southern Mozambique: Cost and cost-effectiveness of mass drug administration combined with intensified malaria control.
PLoS One. 2020 Jul 6;15(7):e0235631. doi: 10.1371/journal.pone.0235631. eCollection 2020.PMID: 32628741
Garcia-Basteiro AL, Hurtado JC, Castillo P, Fernandes F, Navarro M, Lovane L, Casas I, Quintó L, Jordao D, Ismail MR, Lorenzoni C, Carrilho C, Sanz A, Rakislova N, Mira A, Alvarez-Martínez MJ, Cossa A, Cobelens F, Mandomando I, Vila J, Bassat Q, Menendez C, Ordi J, Martínez MJ.
Performance of the Xpert MTB/RIF Ultra Assay for Determining Cause of Death by TB in Tissue Samples Obtained by Minimally Invasive Autopsies.
Chest. 2020 Jul 12:S0012-3692(20)31876-6. doi: 10.1016/j.chest.2020.06.071.
Varo R, Quintó L, Sitoe A, Madrid L, Acácio S, Vitorino P, Valente AM, Mayor A, Camprubí D, Muñoz J, Bambo G, Macete E, Menéndez C, Alonso PL, Aide P, Bassat Q.
Post-malarial anemia in Mozambican children treated with quinine or artesunate: A retrospective observational study.
Int J Infect Dis. 2020 Jun 2;96:655-662. doi: 10.1016/j.ijid.2020.05.089. Online ahead of print.PMID: 32497814
Sanchez L, Vidal M, Jairoce C, Aguilar R, Ubillos I, Cuamba I, Nhabomba AJ, Williams NA, Díez-Padrisa N, Cavanagh D, Angov E, Coppel RL, Gaur D, Beeson JG, Dutta S, Aide P, Campo JJ, Moncunill G, Dobaño C.
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique.
NPJ Vaccines. 2020 Jun 4;5:46. doi: 10.1038/s41541-020-0192-7. eCollection 2020.PMID: 32550014
Muadica AS, Messa AE Jr, Dashti A, Balasegaram S, Santin M, Manjate F, Chirinda P, Garrine M, Vubil D, Acácio S, Köster PC, Bailo B, Nhampossa T, Calero-Bernal R, Mwenda JM, Mandomando I, Carmena D.
First identification of genotypes of Enterocytozoon bieneusi (Microsporidia) among symptomatic and asymptomatic children in Mozambique.
PLoS Negl Trop Dis. 2020 Jun 30;14(6):e0008419. doi: 10.1371/journal.pntd.0008419. Online ahead of print.PMID: 32603325
Wattanakul T, Ogutu B, Kabanywanyi AM, Asante KP, Oduro A, Adjei A, Sie A, Sevene E, Macete E, Compaore G, Valea I, Osei I, Winterberg M, Gyapong M, Adjuik M, Abdulla S, Owusu-Agyei S, White NJ, Day NPJ, Tinto H, Baiden R, Binka F, Tarning J.
 Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria.
Antimicrob Agents Chemother. 2020 Jun 23;64(7):e01848-19. doi: 10.1128/AAC.01848-19. Print 2020 Jun 23.PMID: 32312783
Moncunill G, Scholzen A, Mpina M, Nhabomba A, Hounkpatin AB, Osaba L, Valls R, Campo JJ, Sanz H, Jairoce C, Williams NA, Pasini EM, Arteta D, Maynou J, Palacios L, Duran-Frigola M, Aponte JJ, Kocken CHM, Agnandji ST, Mas JM, Mordmüller B, Daubenberger C, Sauerwein R, Dobaño C.
Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization.
Sci Transl Med. 2020 May 13;12(543):eaay8924. doi: 10.1126/scitranslmed.aay8924.PMID: 32404508
Menéndez C, Quintó L, Castillo P, Carrilho C, Ismail MR, Lorenzoni C, Fernandes F, Hurtado JC, Rakislova N, Munguambe K, Maixenchs M, Macete E, Mandomando I, Martínez MJ, Bassat Q, Alonso PL, Ordi J.
Limitations to current methods to estimate cause of death: a validation study of a verbal autopsy model.
Gates Open Res. 2020 May 28;4:55. doi: 10.12688/gatesopenres.13132.1. eCollection 2020.PMID: 33145479 
Fernández-Luis S, Nhampossa T, Fuente-Soro L, Augusto O, Casellas A, Bernardo E, Ruperez M, Gonzalez R, Maculuve S, Saura-Lázaro A, Menendez C, Naniche D, Lopez-Varela E.
Pediatric HIV Care Cascade in Southern Mozambique: Missed Opportunities for Early ART and Re-engagement in Care.
Pediatr Infect Dis J. 2020 May;39(5):429-434. doi: 10.1097/INF.0000000000002612.PMID: 32091497
Fuente-Soro L, López-Varela E, Augusto O, Bernardo EL, Sacoor C, Nhacolo A, Ruiz-Castillo P, Alfredo C, Karajeanes E, Vaz P, Naniche D.
Loss to follow-up and opportunities for reengagement in HIV care in rural Mozambique: A prospective cohort study.
Medicine (Baltimore). 2020 May;99(20):e20236. doi: 10.1097/MD.0000000000020236.PMID: 32443358
Mandomando I, Vubil D, Boisen N, Quintó L, Ruiz J, Sigaúque B, Nhampossa T, Garrine M, Massora S, Aide P, Nhacolo A, Pons MJ, Bassat Q, Vila J, Macete E, Scheutz F, Levine MM, Ruiz-Perez F, Nataro JP, Alonso PL.
Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone.
PLoS Negl Trop Dis. 2020 May 1;14(5):e0008274. doi: 10.1371/journal.pntd.0008274. eCollection 2020 May.PMID: 32357189
Galatas B, Nhacolo A, Marti H, Munguambe H, Jamise E, Guinovart C, Cirera L, Amone F, Macete E, Bassat Q, Rabinovich R, Alonso P, Aide P, Saute F, Sacoor C.
Demographic and health community-based surveys to inform a malaria elimination project in Magude district, southern Mozambique.
BMJ Open. 2020 May 5;10(5):e033985. doi: 10.1136/bmjopen-2019-033985.PMID: 32371510 
Sevene E, Sharma S, Munguambe K, Sacoor C, Vala A, Macuacua S, Boene H, Mark Ansermino J, Augusto O, Bique C, Bone J, Dunsmuir DT, Lee T, Li J, Macete E, Singer J, Wong H, Nathan HL, Payne BA, Sidat M, Shennan AH, Tchavana C, Tu DK, Vidler M, Bhutta ZA, Magee LA, von Dadelszen P; CLIP Mozambique Working Group.
Community-level interventions for pre-eclampsia (CLIP) in Mozambique: A cluster randomised controlled trial.
Pregnancy Hypertens. 2020 May 14;21:96-105. doi: 10.1016/j.preghy.2020.05.006. Online ahead of print.PMID: 32464527
Gladstone RA, Lo SW, Goater R, Yeats C, Taylor B, Hadfield J, Lees JA, Croucher NJ, van Tonder AJ, Bentley LJ, Quah FX, Blaschke AJ, Pershing NL, Byington CL, Balaji V, Hryniewicz W, Sigauque B, Ravikumar KL, Almeida SCG, Ochoa TJ, Ho PL, du Plessis M, Ndlangisa KM, Cornick JE, Kwambana-Adams B, Benisty R, Nzenze SA, Madhi SA, Hawkins PA, Pollard AJ, Everett DB, Antonio M, Dagan R, Klugman KP, von Gottberg A, Metcalf BJ, Li Y, Beall BW, McGee L, Breiman RF, Aanensen DM, Bentley SD, The Global Pneumococcal Sequencing Consortium.
Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates.
Microb Genom. 2020 May;6(5). doi: 10.1099/mgen.0.000357. Epub 2020 Apr 29.PMID: 32375991
Daniele MAS, Martinez-Alvarez M, Etyang AK, Vidler M, Salisbury T, Makanga PT, Musitia P, Flint-O'Kane M, Brown TW, Diallo BA, Boene H, Stones W, von Dadelszen P, Magee LA, Sandall
The contribution of qualitative research within the PRECISE study in sub-Saharan Africa.
Reprod Health. 2020 Apr 30;17(Suppl 1):58. doi: 10.1186/s12978-020-0875-6.PMID: 32354359
Flint-O'Kane M, von Dadelszen P, Makanga PT, Sevene E, Roca A, Dukes P, Hinrichs-Krapels S, Craik R, Magee LA, Temmerman M; PRECISE Network.
Harnessing the PRECISE network as a platform to strengthen global capacity for maternal and child health research in sub-Saharan Africa.
Reprod Health. 2020 Apr 30;17(Suppl 1):52. doi: 10.1186/s12978-020-0876-5.PMID: 32354358
Magee LA, Strang A, Li L, Tu D, Tumtaweetikul W, Craik R, Daniele M, Etyang AK, D'Alessandro U, Ogochukwu O, Roca A, Sevene E, Chin P, Tchavana C, Temmerman M, von Dadelszen P; PRECISE Network.
The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) database: open-access data collection in maternal and newborn health.
Reprod Health. 2020 Apr 30;17(Suppl 1):50. doi: 10.1186/s12978-020-0873-8.PMID: 32354365
Craik R, Russell D, Tribe RM, Poston L, Omuse G, Okiro P, Chege D, Diatta M, Sesay AK, Cuamba I, Carrilho C, Sevene E, Flint-O'Kane M, von Dadelszen P; PRECISE Network.
PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa.
Reprod Health. 2020 Apr 30;17(Suppl 1):54. doi: 10.1186/s12978-020-0874-7.PMID: 32354368
von Dadelszen P, Flint-O'Kane M, Poston L, Craik R, Russell D, Tribe RM, d'Alessandro U, Roca A, Jah H, Temmerman M, Koech Etyang A, Sevene E, Chin P, Lawn JE, Blencowe H, Sandall J, Salisbury TT, Barratt B, Shennan AH, Makanga PT, Magee LA; PRECISE Network.
The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network's first protocol: deep phenotyping in three sub-Saharan African countries.
Reprod Health. 2020 Apr 30;17(Suppl 1):51. doi: 10.1186/s12978-020-0872-9.PMID: 32354357
Augusto O, Stergachis A, Dellicour S, Tinto H, Valá A, Ruperez M, Macete E, Nakanabo-Diallo S, Kazienga A, Valéa I, d'Alessandro U, Ter Kuile FO, Calip GS, Ouma P, Desai M, Sevene E.
First trimester use of artemisinin-based combination therapy and the risk of low birth weight and small for gestational age.
Malar J. 2020 Apr 8;19(1):144. doi: 10.1186/s12936-020-03210-y.
Farnham A, Cossa H, Dietler D, Engebretsen R, Leuenberger A, Lyatuu I, Nimako B, Zabre HR, Brugger F, Winkler MS.
Investigating Health Impacts of Natural Resource Extraction Projects in Burkina Faso, Ghana, Mozambique, and Tanzania: Protocol for a Mixed Methods Study.
JMIR Res Protoc. 2020 Apr 8;9(4):e17138. doi: 10.2196/17138.PMID: 32266876
Goig GA, Blanco S, Garcia-Basteiro AL, Comas I.
Contaminant DNA in bacterial sequencing experiments is a major source of false genetic variability.
BMC Biol. 2020 Mar 2;18(1):24. doi: 10.1186/s12915-020-0748-z.PMID: 32122347
Hill DL, Carr EJ, Rutishauser T, Moncunill G, Campo JJ, Innocentin S, Mpina M, Nhabomba A, Tumbo A, Jairoce C, Moll HA, van Zelm MC, Dobaño C, Daubenberger C, Linterman MA.
Immune system development varies according to age, location, and anemia in African children.
Sci Transl Med. 2020 Feb 5;12(529):eaaw9522. doi: 10.1126/scitranslmed.aaw9522.PMID: 32024802
Makacha L, Makanga PT, Dube YP, Bone J, Munguambe K, Katageri G, Sharma S, Vidler M, Sevene E, Ramadurg U, Charantimath U, Revankar A, von Dadelszen P
Is the closest health facility the one used in pregnancy care-seeking? A cross-sectional comparative analysis of self-reported and modelled geographical access to maternal care in Mozambique, India and Pakistan.
Int J Health Geogr. 2020 Feb 3;19(1):1. doi: 10.1186/s12942-020-0197-5.PMID: 32013994
Gandasegui J, Martínez-Valladares M, Grau-Pujol B, Krolewiecki AJ, Balaña-Fouce R, Gelaye W, van Lieshout L, Kepha S, Mandomando I, Muñoz J; Stopping Transmission Of intestinal Parasites (STOP) project consortium.
Role of DNA-detection-based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials.
PLoS Negl Trop Dis. 2020 Feb 6;14(2):e0007931. doi: 10.1371/journal.pntd.0007931. eCollection 2020 Feb.PMID: 32027646
The Ivermectin Roadmappers, Billingsley P, Binka F, Chaccour C, Foy B, Gold S, Gonzalez-Silva M, Jacobson J, Jagoe G, Jones C, Kachur P, Kobylinski K, Last A, Lavery JV, Mabey D, Mboera D, Mbogo C, Mendez-Lopez A, Rabinovich NR, Rees S, Richards F, Rist C, Rockwood J, Ruiz-Castillo P, Sattabongkot J, Saute F, Slater H, Steer A, Xia K, Zullinger R.
A Roadmap for the Development of Ivermectin as a Complementary Malaria Vector Control Tool.
Am J Trop Med Hyg. 2020 Feb;102(2s):3-24. doi: 10.4269/ajtmh.19-0620.PMID: 31971144 
Martiáñez-Vendrell X1, Jiménez A1,2, Vásquez A3, Campillo A4, Incardona S4, González R1,2,5, Gamboa D6, Torres K7, Oyibo W8, Faye B9, Macete E5, Menéndez C1,2,5, Ding XC4, Mayor A
Quantification of malaria antigens PfHRP2 and pLDH by quantitative suspension array technology in whole blood, dried blood spot and plasma.
Malar J. 2020 Jan 9;19(1):12. doi: 10.1186/s12936-019-3083-5.
Saverio Bellizzi 1, Giuseppe Pichierri 2, Leonardo Menchini 3, Jessica Barry 4, Giovanni Sotgiu 5, Quique Bassat
The Impact of Underuse of Modern Methods of Contraception Among Adolescents With Unintended Pregnancies in 12 Low- And Middle-Income Countries
J Glob Health
Boene H, Mocumbi S, Högberg U, Hanson C, Valá A, Bergström A, Sevene E, Munguambe K.
Obstetric fistula in southern Mozambique: a qualitative study on women's experiences of care pregnancy, delivery and post-partum.
Reprod Health. 2020 Jan 31;17(1):21. doi: 10.1186/s12978-020-0860-0.PMID: 32005268
Huijben S, Macete E, Mombo-Ngoma G, Ramharter M, Kariuki S, Desai M, Shi YP, Mwangoka G, Massougbodji A, Cot M, Ndam NT, Uberegui E, Gupta H, Cisteró P, Aponte JJ, González R, Menéndez C, Mayor A.
Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy.
J Infect Dis. 2020 Jan 2;221(2):293-303. doi: 10.1093/infdis/jiz451.PMID: 31677349
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